関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | 3-Chloro-2-methylaniline | HCID 6894 | — |
| 反応物 | Formanilide | HCID 7671 | — |
| 反応物 | 1,3-Oxazolidine | HCID 536683 | — |
| 反応物 | 13-aza-6-oxadispiro[4.2.4.I]tridecane | HCID 18316287 | — |
| 生成物 | [1-(Cyclopentylamino)cyclopentyl]methanol | HCID 18316183 | — |
| 生成物 | (1-Aminocyclopentyl)methanol hydrochloride | HCID 23143728 | — |
反応手順
3-Chloro-2-methylaniline was converted to the 3-chloro-2-methylformanilide according to Method A3a, Step 1. The formanilide was converted to 3-chloro-2-methylphenyl isocyanide dichloride according to Method A3a, Step 2. 1-Hydroxymethylcyclopentanamine HCl salt was synthesized according to Method B1c. The 2-hydroxyethylamine was converted to 13-aza-6-oxadispiro[4.2.4. 1]tridecane according to Method B4d, Step 1. The oxazolidine was reductively opened according to Method B4d, Step 2 to give 1-(cyclopentylamino)-1-(hydroxymethyl)cyclopentane. The substituted 2-hydroxyethylamine was converted to 1-(cyclopentylamino)-1-(thioacetylmethyl)cyclopentane according to Method C6c, Step 1. The thioacetate was hydrolyzed according to Method C6c, Step 2 to give 1-(cyclopentylamino)-1-(thiomethyl)cyclopentane. The 2-thioethylamine was reacted with 3-chloro-2-methylphenyl isocyanide dichloride according to Method C6c to afford 2-(3-chloro-2-methylphenylimino)-1-cyclopentyl-3-thia-1-azaspiro[4.4]nonane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06353006B1 |
|---|
| 出典データセット | uspto-grants-2002_03 |
|---|
| ORD ID | ord-0228c29b52a64fada7ab78eb86f55c68 |
|---|
| 出典メモ | uspto-grants-2002_03 |
|---|
