Chloro(phenyl)acetic acid → 2-(2-methyl-4-nitrophenylimino)-3-((1R)-1-cyclohexylethyl)-5-phenyl-1,3-thiazolidin-4-one

HRID 276675

反応式

HRID 276675 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]=[C:12]=[S:13].[NH2:14][C@@H:15]([CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)[CH3:16].Cl[CH:24]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:25](O)=[O:26]>>[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]=[C:12]1[N:14]([C@@H:15]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[CH3:16])[C:25](=[O:26])[CH:24]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[S:13]1

参加物

4

反応物 3

HCID 98950Chloro(phenyl)acetic acidHCID 1456212-Methyl-4-nitrophenyl isothiocyanateHCID 10997046(1R)-1-Cyclohexylethanamine

生成物 1

HCID 229512192-(2-methyl-4-nitrophenylimino)-3-((1R)-1-cyclohexylethyl)-5-phenyl-1,3-thiazolidin-4-one

実験手順

2-Methyl-4-nitrophenyl isothiocyanate was reacted with (1R)-1-amino-1-cyclohexylethane followed by α-chloro-α-phenylacetic acid according to Method C8a to afford 2-(2-methyl-4-nitrophenylimino)-3-((1R)-1-cyclohexylethyl)-5-phenyl-1,3-thiazolidin4-one.

出典と根拠

ORDレコード
ord-ab9ce2f9f9de422995bd9bf0c1cfff94
出典データセット
uspto-grants-2002_03
特許番号
US06353006B1

関連ノート

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