5-Chlorothieno[3,2-b]pyridine-2-sulfonyl chloride → 5-Chlorothieno[3,2-b]pyridine-2-sulfonic acid [1-(5-cyanothiophen-3-ylmethyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

HRID 2767

反応式

HRID 2767 の反応式
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([C:14]#[N:15])[S:12][CH:13]=2)[C:4]1=[O:16].[Cl:17][C:18]1[N:23]=[C:22]2[CH:24]=[C:25]([S:27](Cl)(=[O:29])=[O:28])[S:26][C:21]2=[CH:20][CH:19]=1>>[C:14]([C:11]1[S:12][CH:13]=[C:9]([CH2:8][N:5]2[CH2:6][CH2:7][C@H:3]([NH:2][S:27]([C:25]3[S:26][C:21]4[C:22](=[N:23][C:18]([Cl:17])=[CH:19][CH:20]=4)[CH:24]=3)(=[O:28])=[O:29])[C:4]2=[O:16])[CH:10]=1)#[N:15]

参加物

3

反応物 2

HCID 220172995-Chlorothieno[3,2-b]pyridine-2-sulfonyl chlorideHCID 228836294-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-thiophene-2carbonitrile hydrochloride

生成物 1

HCID 543794875-Chlorothieno[3,2-b]pyridine-2-sulfonic acid [1-(5-cyanothiophen-3-ylmethyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

実験手順

The title compound is prepared from 4-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-thiophene-2carbonitrile hydrochloride as described in EXAMPLE 1, Part E using 5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride in place of benzo[b]thiophene-2-sulfonyl chloride. The product is triturated with Et2O/CH2Cl2 /hexanes to give a white solid.

後処理

  1. customThe product is triturated with Et2O/CH2Cl2 /hexanes
  2. customto give a white solid

出典と根拠

ORDレコード
ord-394fa6eeedf64e31a0dbc91c22f2c1e3
出典データセット
uspto-grants-1998_03
特許番号
US05731315

関連ノート

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