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Formanilide → Aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formanilide | HCID 7671 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 触媒 | Cupric Chloride | HCID 24014 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | Copper Sulfate | HCID 24462 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | Aniline | HCID 6115 | 84.1% |
| 生成物 | Formanilide | HCID 7671 | — |
反応手順
The procedure of Example I is repeated except that 12.65 g (125 mmoles) of triethylamine is substituted for the pyridine and a mixture of 4.12 g (25 mmoles) of anhydrous copper(II) sulfate and 0.55 g (2.8 mmoles) of anhydrous copper(I) iodide is substituted for the copper(II) chloride. A strong exotherm and a rapid pressure drop of about 1125 psi over the course of a 180 minute residence period is observed. GLC and ALC analyses indicate that 12.56 g (103.7 mmoles) formanilide is formed. Based on aniline as the limiting reagent, a selectivity of 49.3 mole % formanilide at 84.1% aniline conversion is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04222959 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-913421370b914c17ad3002f161a8244b |
| 出典メモ | uspto-grants-1980_09 |