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Ethanolamine → HCID 178426704、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | D-Leucine, methyl ester | HCID 89967 | — |
| 反応物 | D(-)-Leucinol | HCID 2724002 | — |
| 反応物 | 2-Isothiocyanato-1-methyl-4-nitrobenzene | HCID 2759955 | — |
| 生成物 | HCID 178426704 | HCID 178426704 | — |
反応手順
(1R)-1-(Hydroxymethyl)-3-methylbutylamine was made from (D)-leucine methyl ester according to B1b. The 2-hydroxyethylamine was converted to (1R)-1-(chloromethyl)-3-methylbutanammonium chloride as described in Method B7a. 2-Methyl-5-nitrophenyl isothiocyanate was reacted with (1R)-1-(chloromethyl)-3-methylbutanammonium chloride according to Method C1a to give (4R)-2-(2-methyl-5-nitrophenylimino)-4-isobutyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford (4R)-2-(N-isobutyl-N-(2-methyl-5-nitrophenyl)amino)-4-isobutyl-1,3-thiazoline HCl salt.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06353006B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-bfe44d4a75de4d2ebbb78a3da7eb652f |
| 出典メモ | uspto-grants-2002_03 |