Water → Ethanol, 2-(ethylphenylamino)-, 1-acetate

HRID 276743

反応式

HRID 276743 の反応式
[CH2:1]([N:3]([CH2:10][CH2:11][OH:12])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:2].C(N(CC)CC)C.[C:20](Cl)(=[O:22])[CH3:21].O>CC(C)=O>[C:20]([O:12][CH2:11][CH2:10][N:3]([CH2:1][CH3:2])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1)(=[O:22])[CH3:21]

参加物

6

反応物 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 623382-(N-ethylanilino)ethanol

生成物 1

HCID 113382Ethanol, 2-(ethylphenylamino)-, 1-acetate収率 99.9%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

51.8 g of 2-(N-ethylanilino)ethanol and 31.7 g of triethylamine were dissolved in 300 ml of acetone. To this was added slowly 25 g of acetyl chloride while cooling the resulting reaction solution with ice water. The resulting solution was then stirred for 6 hours at room temperature for reaction. 200 ml of water was then poured into the solution. The organic layer was extracted with ethyl acetate and dried with sodium sulfate. The solvent was then distilled off under reduced pressure to obtain 64.9 g of 2-(N-ethylanilino)ethyl acetate.

後処理

  1. temperaturewhile cooling
  2. extractionThe organic layer was extracted with ethyl acetate
  3. dry with materialdried with sodium sulfate
  4. distillationThe solvent was then distilled off under reduced pressure

出典と根拠

ORDレコード
ord-bd2e94ce3b8043488d2dd31264c76a54
出典データセット
uspto-grants-2002_03
特許番号
US06355396B1

関連ノート

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