1-(4-Chlorophenyl)-2-methylpiperazine → 2-Methyl-1-phenylpiperazine

HRID 276891ノート

反応式

HRID 276891 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH:9]2[CH3:14])=[CH:4][CH:3]=1.[H][H]>CO.[C].[Pd]>[C:5]1([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH:9]2[CH3:14])[CH:4]=[CH:3][CH:2]=[CH:7][CH:6]=1

参加物

5

反応物 2

HCID 982891-(4-Chlorophenyl)-2-methylpiperazineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 980862-Methyl-1-phenylpiperazine収率 100%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

1-(4-chlorophenyl)-2-methylpiperazine (300 mg, 1.4 mmol) was dissolved in methanol (3 ml), and the resulting solution was mixed with palladium carbon (150 mg) and stirred at a room temperature for 21 hours in an atmosphere of hydrogen. The reaction solution was filtered, and the thus obtained residue was thoroughly washed with ethanol. The washed solution and filtrate were combined, and the solvent was evaporated therefrom under a reduced pressure to obtain 260 mg of the title compound (1.4 mmol, 100% in yield).

後処理

  1. filtrationThe reaction solution was filtered
  2. washthe thus obtained residue was thoroughly washed with ethanol
  3. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-5f1c9b4ff6e7447ebc3163247c5f535a
出典データセット
uspto-grants-2002_03
特許番号
US06355642B1

反応ノート

読み込み中…