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Acetonitrile → Benzo[b]thiophene-2-sulfonic acid [1-(4-amino-3-cyanobenzyl)-2-oxo-pyrrolidin-3-(S)-yl]amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | 1-Benzothiophene-2-sulfonyl chloride | HCID 2776333 | — |
| 反応物 | 4-amino-3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)benzonitrile dihydrochloride | HCID 22883631 | — |
| 生成物 | Benzo[b]thiophene-2-sulfonic acid [1-(4-amino-3-cyanobenzyl)-2-oxo-pyrrolidin-3-(S)-yl]amide | HCID 53897651 | — |
反応手順
The title compound (0.131 g, 0.307 mmol) is prepared as in EXAMPLE 1, Part E from 4-amino-3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)benzonitrile dihydrochloride (0.135 g, 0.445 mmol) and benzo[b]thiophene-2-sulfonyl chloride (0.114 g, 0.49 mmol) in acetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05731315 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-2304608b9689445eb80f2a17289a2a83 |
| 出典メモ | uspto-grants-1998_03 |