(E)-3-(2-ethyl-pyridin-4-yl)-acrylonitrile → 7-(2-Ethyl-pyridin-4-yl)-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

反応式

C1(S([CH2:10][C:11]2[N:15]=[C:14]([C:16]3[O:17][CH:18]=[CH:19][CH:20]=3)[NH:13][N:12]=2)(=O)=O)C=CC=CC=1.[CH2:21]([C:23]1[CH:28]=[C:27](/[CH:29]=[CH:30]/[C:31]#[N:32])[CH:26]=[CH:25][N:24]=1)[CH3:22]>>[CH2:21]([C:23]1[CH:28]=[C:27]([C:29]2[CH:30]=[C:31]([NH2:32])[N:12]3[N:13]=[C:14]([C:16]4[O:17][CH:18]=[CH:19][CH:20]=4)[N:15]=[C:11]3[CH:10]=2)[CH:26]=[CH:25][N:24]=1)[CH3:22]

参加物

反応物 2

HCID 22629691(E)-3-(2-ethyl-pyridin-4-yl)-acrylonitrile

HCID 178527402HCID 178527402、化合物

生成物 1

HCID 226296987-(2-Ethyl-pyridin-4-yl)-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

実験手順

The title compound, mp. 184-186° C. and MS m/e (%): 305 (M+, 100), was prepared in accordance with the general method of example 1 from 3-benzenesulfonylmethyl-5-furan-2-yl-1H-[1,2,4]triazole and (E)-3-(2-ethyl-pyridin-4-yl)-acrylonitrile.

出典と根拠

ORDレコード: ord-207d707d09294bba8ff5a99f5bde78c2
出典データセット: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06355653B1

反応ノート

読み込み中…