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3-Methyl-2-thiophenecarboxaldehyde → 7-Bromo-2-(3-methyl-thiophen-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methyl-2-thiophenecarboxaldehyde | HCID 79911 | — |
| 反応物 | 4-Bromo-2,6-diaminopyridine | HCID 11435393 | — |
| 反応物 | O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine | HCID 11830845 | — |
| 生成物 | 7-Bromo-2-(3-methyl-thiophen-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine | HCID 18313692 | — |
反応手順
The title compound, MS m/e (%): 309 (M+, 100), was prepared in accordance with the general method of example 63 from 4-bromo-pyridine-2,6-diamine, O-mesitylene-sulfonylhydroxylamine, and 3-methylthiophene-2-carboxaldehyde. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06355653B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-e22fa2c3d371489a8a509ce5670f088a |
| 出典メモ | uspto-grants-2002_03 |