5-Ethyl-2-furaldehyde → 7-Bromo-2-(5-ethyl-furan-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

HRID 277072

反応式

HRID 277072 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH2:9])[CH:3]=1.C1(C)C=C(C)C=C(C)C=1S(O[NH2:22])(=O)=O.[CH2:24]([C:26]1[O:30][C:29]([CH:31]=O)=[CH:28][CH:27]=1)[CH3:25]>>[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]2[N:22]=[C:31]([C:29]3[O:30][C:26]([CH2:24][CH3:25])=[CH:27][CH:28]=3)[N:9]=[C:4]2[CH:3]=1

参加物

4

反応物 3

HCID 899895-Ethyl-2-furaldehydeHCID 114353934-Bromo-2,6-diaminopyridineHCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

生成物 1

HCID 183136977-Bromo-2-(5-ethyl-furan-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

実験手順

The title compound, MS m/e (%): 309 (M++2, 100), was prepared in accordance with the general method of example 63 from 4-bromo-pyridine-2,6-diamine, O-mesitylene-sulfonylhydroxylamine, and 5-ethyl-2-furaldehyde. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.

出典と根拠

ORDレコード
ord-001530a074d2446a8ab529134afa798a
出典データセット
uspto-grants-2002_03
特許番号
US06355653B1

関連ノート

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