(Z)-3-pyridin-4-yl-acrylonitrile → 2-(2,4-Difluoro-phenyl)-7-pyridin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

反応式

C1(S([CH2:10][C:11]2[N:15]=[C:14]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=3[F:23])[NH:13][N:12]=2)(=O)=O)C=CC=CC=1.[N:24]1[CH:29]=[CH:28][C:27](/[CH:30]=[CH:31]\[C:32]#[N:33])=[CH:26][CH:25]=1>>[F:23][C:17]1[CH:18]=[C:19]([F:22])[CH:20]=[CH:21][C:16]=1[C:14]1[N:15]=[C:11]2[CH:10]=[C:30]([C:27]3[CH:28]=[CH:29][N:24]=[CH:25][CH:26]=3)[CH:31]=[C:32]([NH2:33])[N:12]2[N:13]=1

参加物

反応物 2

HCID 45079944(Z)-3-pyridin-4-yl-acrylonitrile

HCID 178527400HCID 178527400、化合物

生成物 1

HCID 183135902-(2,4-Difluoro-phenyl)-7-pyridin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

実験手順

The title compound, MS m/e (%): 323 (M+, 100), 303 (60), was prepared in accordance with the general method of example 1 from 3-benzenesulfonylmethyl-5-(2,4-difluoro-phenyl)-1H-[1,2,4]triazole and (E)/(Z)-3-pyridin-4-yl-acrylonitrile.

出典と根拠

ORDレコード: ord-0431e2ca60aa474f9063815e542e89f9
出典データセット: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06355653B1

反応ノート

読み込み中…