反応式
[NH2:1][C:2]1[C:7]([O:8]C)=[C:6]([Cl:10])[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]([CH3:23])[C:13]1=[O:24].C(Cl)Cl>ClCCCl>[NH2:1][C:2]1[C:7]([OH:8])=[C:6]([Cl:10])[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]([CH3:23])[C:13]1=[O:24]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
3-(2-Amino-4-chloro-6-fluoro-3-methoxyphenyl)-1-methyl-6trifluoromethyl-2,4(1H, 3H)-pyrimidinedione (1.1 g, 2.7 mmol) was dissolved in 50 ml of anhydrous 1,2-dichloroethane and 3.4 g (10.8 mmol) of borontribromide imethylsulfide complex was added to the solution. The solution was refluxed for 16 hr and methylene chloride (100 ml) was added. Washing with water followed by drying (anhydrous sodium sulfate) and removal of the solvent afforded a residue which was triturated with ether to afford the title compound (0.6 g).
後処理
- addition3.4 g (10.8 mmol) of borontribromide imethylsulfide complex was added to the solution
- temperatureThe solution was refluxed for 16 hr
- washWashing with water
- customby drying
- custom(anhydrous sodium sulfate) and removal of the solvent
- customafforded a residue which
- customwas triturated with ether
出典と根拠
- ORDレコード
- ord-5a7f1aac39f3483da73a2db568028b8f
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06355799B1
関連ノート
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