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Water → 2-(4-Benzyloxyphenylmethylene)-4-methyl-3-oxopentanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Benzaldehyde, 4-(phenylmethoxy)- | HCID 78109 | — |
| 反応物 | 4-methyl-3-oxo-N-phenylpentanamide | HCID 10219899 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 2-(4-Benzyloxyphenylmethylene)-4-methyl-3-oxopentanamide | HCID 54048391 | — |
反応手順
Step A—A solution of 4-methyl-N-phenyl-3-oxopentanamide, 12, (5 mmol), 4-benzyloxybenzaldehyde (5 mmol) and pyridine (1 mL) in xylene (100 mL) is heated at reflux, with azeotropic removal of water. The progress of the reaction is monitored by tlc. When the reaction is complete, the solvent is removed under reduced pressure, and the residue is chromatographed to afford 2-(4-benzyloxyphenylmethylene)-4-methyl-3-oxopentanamide, 13, (R=4-benzyloxy).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06355810B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-dd175ec9fb224853972661988935f5aa |
| 出典メモ | uspto-grants-2002_03 |