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Water → 5-Cyano-6-methyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sec-Butylamine | HCID 24874 | — |
| 反応物 | Ethyl 2-chloro-5-cyano-6-methylnicotinate | HCID 2758816 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-Cyano-6-methyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester | HCID 86737219 | — |
反応手順
22.4 g of 2-chloro-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester (1 mol) of Example 1(b) are treated in 100 ml of ethanol with 15 g sec. butylamine at reflux temperature with stirring. After the addition of the amine is completed, the solution is poured into 200 ml of cold water, and the amino compound is filtered off. Yield 22 g (84%); m.p. 55°-57° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04223142 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-8ae000ca848e414ea1ff080f0b71df04 |
| 出典メモ | uspto-grants-1980_09 |