Selenium Dioxide → 5-Cyano-6-formyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester
反応式
[C:1]([C:3]1[CH:4]=[C:5]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:6]([NH:10][CH:11]([CH3:14])[CH2:12][CH3:13])=[N:7][C:8]=1[CH3:9])#[N:2].[Se](=O)=[O:21]>O1CCOCC1>[C:1]([C:3]1[CH:4]=[C:5]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:6]([NH:10][CH:11]([CH3:14])[CH2:12][CH3:13])=[N:7][C:8]=1[CH:9]=[O:21])#[N:2]参加物
4
実験手順
26.1 g of 5-cyano-6-methyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester (0.1 mol) and 13 g of selenium dioxide are refluxed together in dioxane for 24 hours. After this time the selenium is filtered off and the solvent removed in vacuo. The resulting oily residue is crystallized with ether. Yield 19 g (69%); m.p. 37°-38° C. (methanol).
後処理
- filtrationAfter this time the selenium is filtered off
- customthe solvent removed in vacuo
- customThe resulting oily residue is crystallized with ether
出典と根拠
- ORDレコード
- ord-2262b51bdca24ee2979efa35425d1902
- 出典データセット
- uspto-grants-1980_09
- 特許番号
- US04223142
反応ノート
読み込み中…