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Triethylamine → HCID 22625351、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | ((p-(Benzyloxy)phenoxy)methyl)oxirane | HCID 119882 | — |
| 反応物 | 1-(2,4-Dimethoxyphenyl)piperazine dihydrochloride | HCID 22625378 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | HCID 22625351 | HCID 22625351 | 67.3% |
反応手順
Using 1.56 g of 1-(4-benzyloxyphenoxy)-2,3-epoxypropane, 1.80 g of 1-(2,4-dimethoxyphenyl)piperazine dihydrochloride, 1.9 ml of triethylamine and 50 ml of dioxane, reaction and workup were carried out as in Example 1-A. Purification by column chromatography (silica gel, elution with ethyl acetate:hexane =1:0.5) gave 1.96 g of pale red crystals, m.p. 110-112° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06358515B2 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-0f1cbbe117464338a1abcdc98b305f2c |
| 出典メモ | uspto-grants-2002_03 |