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1,4-Dioxane → 1-(4-Benzyloxyphenoxy)-3-[4-(2-methoxy-5-methylphenyl)-1-piperazinyl]propan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | ((p-(Benzyloxy)phenoxy)methyl)oxirane | HCID 119882 | — |
| 反応物 | 1-(2-Methoxy-5-methylphenyl)piperazine dihydrochloride | HCID 22625397 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 1-(4-Benzyloxyphenoxy)-3-[4-(2-methoxy-5-methylphenyl)-1-piperazinyl]propan-2-ol | HCID 22625405 | 89.5% |
反応手順
Using 1.37 g of 1-(4-benzyloxyphenoxy)-2,3-epoxypropane, 50 ml of dioxane, 1.49 g of 1-(2-methoxy-5-methylphenyl)piperazine dihydrochloride and 1.6 ml of triethylamine, reaction and workup were carried out as in Example 1-A. Purification by column chromatography (silica gel, elution with ethyl acetate:hexane=1:1) gave 2.21 g of pale yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06358515B2 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-69d41a5bc4b94670b9a110e6d04c642f |
| 出典メモ | uspto-grants-2002_03 |