3H-Indole, 2,3,3-trimethyl- → n-(5-Carboxypentyl)-2,3,3-trimethylindolinium bromide

反応式

[CH3:1][C:2]1[C:10]([CH3:12])([CH3:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20]>>[Br-:13].[C:19]([CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][NH+:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:10]([CH3:12])([CH3:11])[CH:2]1[CH3:1])([OH:21])=[O:20]

参加物

反応物 2

HCID 154273H-Indole, 2,3,3-trimethyl-

HCID 202106-Bromohexanoic acid

生成物 1

HCID 18764706n-(5-Carboxypentyl)-2,3,3-trimethylindolinium bromide

実験手順

N-(5-carboxypentyl)-2,3,3-trimethylindolinium bromide was prepared by the process set forth in Example IA with 2,3,3-trimethylindolenine and 6-bromohexanoic acid to produce 2.43 grams (71.2 percent yield) of yellow crystals. 1H and 13C NMR spectra indicated the following:

出典と根拠

ORDレコード: ord-3899277ff86e4ff982f05beaa57e671e
出典データセット: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06358655B1

反応ノート

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