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Water → 1,2-Dimethylbenzimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | 2-Methylbenzimidazole | HCID 11984 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 1,2-Dimethylbenzimidazole | HCID 312693 | 54.2% |
反応手順
To 10 grams of 2-methyl benzimidazole (75 mM), crushed 25 grams of crushed KOH (450 mM) in 300 ml acetone, methyl iodide (15 grams, 105 mM) was added at a continuous drip for 0.5 hours, at room temperature. Following additional 0.5 hour, water was added, the reaction extracted with dichloromethane, evaporated and chromatographed on silica gel to yield 6 grams (54%) of 1,2-dimethyl benzimidazole as a white solid having a melting point of 102° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06358954B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-e1a98b1a47df4324be83e13f054dcad2 |
| 出典メモ | uspto-grants-2002_03 |