関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 4-Methylbenzene-1-carboximidamide hydrochloride | HCID 122753 | — |
| 反応物 | 1,1-Dihydroxypropan-2-one | HCID 13180982 | — |
| 溶媒 | Ammonium Hydroxide | HCID 14923 | — |
| 生成物 | 2-(p-Tolyl)imidazole-5-methanol | HCID 13011242 | — |
反応手順
A solution of 4 g 4-methylbenzamidine hydrochloride in 60 mL ammonium hydroxide was treated with 4.0 g with dihydroxyacetone and 4.8 g ammonium chloride. The reaction mixture was heated to 90° C. for 4 hours in a sealed tube. On cooling to room temperature a the solid formed was collected by filtration to yield 3.0 g 2-(4-methylphenyl)-5-hydroxymethyl-imidazole which was converted according to the procedure described in Example VII to yield 2-(4-methylphenyl-4(5)-[(4-(2-pyrimidinyl)-piperazin-1-yl)-methyl]-imidazole (Compound 133), m.p. 178-180° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06358955B1 |
|---|
| 出典データセット | uspto-grants-2002_03 |
|---|
| ORD ID | ord-eb9e6dfdad7f4a07895fb90217f1a43f |
|---|
| 出典メモ | uspto-grants-2002_03 |
|---|
