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2-Phenylethanol → Ethyl Acetoacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Phenylethanol | HCID 6054 | — |
| 反応物 | 2,2-Diethoxyethylamine | HCID 69524 | — |
| 反応物 | 3,4-Dimethoxyphenethyl alcohol | HCID 81911 | — |
| 生成物 | Ethyl Acetoacetate | HCID 8868 | — |
| 生成物 | 1-Methyl-1-isochromanacetic acid ethyl ester | HCID 54257169 | — |
反応手順
In the same manner but replacing 3,4-dimethoxyphenethyl alcohol and aminoacetaldehyde diethyl acetal with equivalent amounts of phenethyl alcohol, Khafagy and Lambooy, cited above, and ethyl acetoacetate, respectively, 1-methyl-1-isochromanacetic acid ethyl ester, νmaxCHCl3 1720 cm-1, nmr (CDCl3) δ1.5, 2.85, is obtained. Likewise, replacement with equivalent amounts of 1-naphthaleneethanol, M. Mousseron and Nguyen-Phuoc-Du. Bull. Soc. Chim. Fr., 91 (1948), and ethyl acetoacetate, gives 1,2-dihydro-4-methyl-4H-naphtho[2,1-c]-pyran-4-acetic acid ethyl ester, νmaxCHCl3 1720 cm-1, nmr (CDCl3) δ1.5. Hydrogen bromide is a preferred acid catalyst for these latter two preparations.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04223151 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-b6c1b5550c2a4f4f80fcb4ae26c3c1dd |
| 出典メモ | uspto-grants-1980_09 |