関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | Proton sponge | HCID 88675 | — |
| 反応物 | Phenethylamine, m-trifluoromethyl- | HCID 104223 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 22625918 | HCID 22625918 | — |
反応手順
To a methylene chloride solution of commercially available 2-(3-trifluoromethylphenyl)ethylamine (5.65 mmol) at 0° C. was added solid Proton sponge (5.65 mmol) then a 20% solution of phosgene in toluene (5.65 mmol). The solution was stirred at 25° C. for 1 hour and then washed with 1N HCl (40 mL). The methylene chloride was then dried with sodium sulfate and evaporated. 1H-NMR (CDCl3): 7.5 ppm (m, 4H); 3.6 ppm (t, 2H); 2.95 ppm (t, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06358956B1 |
|---|
| 出典データセット | uspto-grants-2002_03 |
|---|
| ORD ID | ord-14752c278bc741549bd1462504deb75d |
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| 出典メモ | uspto-grants-2002_03 |
|---|
