Ammonia → (6-Aminopyridin-3-yl)(phenyl)methanone

HRID 277921ノート

反応式

HRID 277921 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][N:3]=1.[NH3:16]>CCO>[NH2:16][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 3061713Methanone, (6-chloro-3-pyridinyl)phenyl-

生成物 1

HCID 13015392(6-Aminopyridin-3-yl)(phenyl)methanone

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
145 °C

実験手順

The 2-chloro-5-benzoylpyridine (100 g, 0.460 mol) was dissolved in 500 ml of 3A EtOH and 400 ml of anhydrous ammonia, placed in a bomb, then heated at 145° C. for 16 hours. The solvents were removed in vacuo and the remaining tan solid was recrystallized from EtOH/H2O yielding 77.4 g (85%) of product as a tan solid. EA, MS(FD).

後処理

  1. customThe solvents were removed in vacuo
  2. customthe remaining tan solid was recrystallized from EtOH/H2O yielding 77.4 g (85%) of product as a tan solid

出典と根拠

ORDレコード
ord-fbad836a3d4e4655908c7d0d9f740b7e
出典データセット
uspto-grants-2002_03
特許番号
US06358971B1

反応ノート

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