化工社化工社 化学情報印刷レポート · 研究参考用
Benzoyl Peroxide → Bromo(4-fluorophenyl)acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl Peroxide | HCID 7187 | — |
| 反応物 | 2-(4-Fluorophenyl)acetic acid | HCID 9837 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | Bromo(4-fluorophenyl)acetic acid | HCID 16217752 | — |
反応手順
The 4-fluorophenylacetic acid (20 g, 0.13 mol), benzoyl peroxide (130 mg, 0.540 mmol), and N-bromosuccinimide (23.1 g, 0.130 mol) were combined in 500 ml carbon tetrachloride under N2 and refluxed under UV irradiation (GE sunlamp) for 5 hours. The reaction was cooled to RT and the succinimide filtered away. The carbon tetrachloride was removed in vacuo and the remaining oil recrystallized from hexanes yielding 26.2 g (87%) of product as a light yellow solid. EA, MS(FD).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06358971B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-df6e30e07dca4e87a46146c58d561673 |
| 出典メモ | uspto-grants-2002_03 |