Water → 2-(4-Bromophenyl)-3,3,3-trifluoronitropropene
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=1.[CH3:14][N+:15]([O-:17])=[O:16].O>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:9]([F:12])([F:11])[F:10])=[CH:14][N+:15]([O-:17])=[O:16])=[CH:4][CH:3]=1参加物
5
実験手順
A stirred solution of 4′-bromo-2,2,2-trifluoroacetophenone (0.392 g, 2.00 mmol) and CH3NO2 (0.488 g, 8.0 mmol) in dry toluene (70 mL) containing N,N-diethylenediamine (30 mmol) is heated at reflux with a Dean and Stark trap until complete removal of H2O. The cooled solution is washed with 5% aqueous HCl, dried over MgSO4, filtered, evaporated in vacuo and the resulting residue when purified by chromatography gives the title compound.
後処理
- temperatureis heated
- washThe cooled solution is washed with 5% aqueous HCl
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated in vacuo
- customthe resulting residue when purified by chromatography
出典と根拠
- ORDレコード
- ord-6e7c6eda8900428385b49fc10c46cf74
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06358981B1
反応ノート
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