2-(3-Cyanopropyl)-1,3-dioxolane → 2-(4-Aminobutyl)-1,3-dioxolane
反応式
[C:1]([CH2:3][CH2:4][CH2:5][CH:6]1[O:10][CH2:9][CH2:8][O:7]1)#[N:2].[H][H]>N.C(O)C.[Ru]>[NH2:2][CH2:1][CH2:3][CH2:4][CH2:5][CH:6]1[O:10][CH2:9][CH2:8][O:7]1参加物
6
実験手順
To a solution of 14.5 gm (10.3 mmol) 2-(3-Cyanopropyl)-1,3-dioxolane in anhydrous ammonia and ethanol was added 5% ruthenium on aluminum oxide. The reaction mixture was hydrogenated with an initial hydrogen pressure of 100 p.s.i. at ambient temperature for 32 hours. The reaction mixture was filtered and the filtrate concentrated under reduced pressure. The residue was purified by silica gel chromatography to give 12.0 gm (80.5%) of the product. MS (FD+) (m/e): 146.
後処理
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate concentrated under reduced pressure
- customThe residue was purified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-720a3c0dc19a459f94cd736d115f9ba1
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06358972B1
反応ノート
読み込み中…