Potassium Hydroxide → HCID 22627677、化合物

A mixture of ethyl 2-(isopropylthio)-2-methylpropionate (5.4 g, 30 mmol) and potassium hydroxide (5.0 g, 90 mmol) in ethanol is refluxed for 6 hours, cooled, and concentrated in vacuo to obtain a residue. The residue is diluted with water, washed with ether, acidified with hydrochloric acid, and extracted with ether. The combined organic extracts are washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a solid. The solid is washed with chloroform and dried under reduced pressure to give the title product as a solid, mp 51.5-52.5° C.

1. temperatureis refluxed for 6 hours
2. temperaturecooled
3. concentrationconcentrated in vacuo
4. customto obtain a residue
5. washwashed with ether
6. extractionextracted with ether
7. washThe combined organic extracts are washed sequentially with water and brine
8. dry with materialdried over anhydrous magnesium sulfate
9. concentrationconcentrated in vacuo
10. customto obtain a solid
11. washThe solid is washed with chloroform
12. customdried under reduced pressure

ORDレコード

ord-0e9ebb424c524824b57dba70cf1006b6

出典データセット

uspto-grants-2002_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06359009B1