Acetyl chloride → HCID 11043471、化合物

反応式

[Cl-].[Al+3].[Cl-].[Cl-].[C:5](Cl)(=[O:7])[CH3:6].[CH2:9]([C:12]1[NH:13][C:14]2[C:19]([CH:20]=1)=[CH:18][CH:17]=[C:16]([C:21]([O:23][CH3:24])=[O:22])[CH:15]=2)[CH2:10][CH3:11]>ClCCl>[C:5]([C:20]1[C:19]2[C:14](=[CH:15][C:16]([C:21]([O:23][CH3:24])=[O:22])=[CH:17][CH:18]=2)[NH:13][C:12]=1[CH2:9][CH2:10][CH3:11])(=[O:7])[CH3:6]

参加物

反応条件

温度: 20 °C

実験手順

To a stirring suspension of aluminum chloride (294 mg) and acetyl chloride (0.08 ml) in dichloromethane (10 ml) was added methyl 2-propylindole-6-carboxylate (200 mg), and the mixture was stirred at 20° C. for 1 hour. The resulting mixture was poured onto ice and extracted with ethyl acetate. The combined organic chase was washed with aqueous sodium bicarbonate and brine, then dried over sodium sulfate and evaporated in vacuo. The residue was triturated with isopropyl ether to give methyl 3-acetyl-2-propylindole-6-carboxylate (78 mg) as colorless crystals.