化工社化工社 化学情報印刷レポート · 研究参考用
Aluminum(III) Chloride → Ibuprofen, (+-)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 反応物 | 2-(p-Isobutylphenyl)propionic acid benzyl ester | HCID 10424662 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Nitromethane | HCID 6375 | — |
| 溶媒 | Anisole | HCID 7519 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Ibuprofen, (+-)- | HCID 3672 | 91% |
反応手順
To a solution of benzyl 2-p-isobutylphenylpropionate (3 g) in methylene chloride (18 ml) are added a solution of aluminum chloride (4 g) in nitromethane (50 ml) and anisole (3 ml) at 0° C., and the mixture is stirred at room temperature for 6 hours. The reaction mixture is diluted with ethyl acetate, washed with hydrochloric acid and water, dried and evaporated. The residue is recrystallized with n-hexane to give 2-p-isobutylphenylpropionic acid (186 mg) melting at 75°-77.5° C. Yield 91%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04223132 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-fe55e9d7d722407189fc1a59ff07f4bc |
| 出典メモ | uspto-grants-1980_09 |