Potassium Carbonate → Methyl 2-acetamido-3-hydroxybenzoate

HRID 278083ノート

反応式

HRID 278083 の反応式
[C:1]([NH:4][C:5]1[C:14]([O:15]C(=O)C)=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:1]([NH:4][C:5]1[C:14]([OH:15])=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 22627220Methyl 2-acetamido-3-acetoxybenzoate

生成物 1

HCID 22627296Methyl 2-acetamido-3-hydroxybenzoate収率 84.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of methyl 2-acetamido-3-acetoxybenzoate (1.72 g) in methanol (9 ml) was added powdered potassium carbonate (1.4 g), and the mixture was stirred for 20 minutes. The resulting solid was removed by filtration and washed with methanol. The filtrate was evaporated in vacuo, and the residue was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate and evaporated in vacuo. The residue was triturated with a mixture of isopropyl ether and hexane to give methyl 2-acetamido-3-hydroxybenzoate (1.21 g) as solid.

後処理

  1. customThe resulting solid was removed by filtration
  2. washwashed with methanol
  3. customThe filtrate was evaporated in vacuo
  4. extractionextracted with ethyl acetate
  5. washThe organic phase was washed with brine
  6. dry with materialdried over sodium sulfate
  7. customevaporated in vacuo
  8. customThe residue was triturated with a mixture of isopropyl ether and hexane

出典と根拠

ORDレコード
ord-b89ac08045ae4d5d95c7153dcb196fbd
出典データセット
uspto-grants-2002_03
特許番号
US06358992B1

反応ノート

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