化工社化工社 化学情報印刷レポート · 研究参考用
4-Bromoaniline → 6-Bromoquinolin-2(1H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromoaniline | HCID 7807 | — |
| 反応物 | 3-Phenylprop-2-enoyl chloride | HCID 66023 | — |
| 生成物 | 6-Bromoquinolin-2(1H)-one | HCID 12378943 | — |
| 生成物 | 6-Bromo-2-chloroquinoline | HCID 12894086 | — |
反応手順
The title compound is prepared from 4-bromoaniline and cinnamoyl chloride according to the procedure described in J. Chem. Soc., Perkin Trans. I, 1972, 1648. The crude 6-bromo-1H-quinolin-2-one intermediate obtained is triturated in Et2O/hexanes and filtered to give a beige solid which is used directly in the chlorination step. The crude product is recrystallized in MeOH to afford the title compound as a beige solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05731315 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-d45dd22efe384d6e8d41b31969ccab08 |
| 出典メモ | uspto-grants-1998_03 |