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Ethylene Glycol → 2-[2-(Methylsulfanyl)ethyl]-1,3-dioxolane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylene Glycol | HCID 174 | — |
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Methional | HCID 18635 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-[2-(Methylsulfanyl)ethyl]-1,3-dioxolane | HCID 20398666 | — |
反応手順
1040 g (10 moles) of freshly distilled methional, 650 g (10.5 moles) of ethylene glycol, 400 cc of benzene, 800 cc of dioxan and 10 g of p-toluene sulphonic acid are heated under reflux until the azeotropic entrainment of the water formed during the reaction, which takes 2 hours, is over. The acid medium is then neutralised by the addition of 10 g of dry sodium carbonate, after which the solution is concentrated to dryness in a water pump vacuum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04224051 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-b2697c3787e841e894f29b50e8b016e9 |
| 出典メモ | uspto-grants-1980_09 |