Hydrochloric Acid → HCID 131723149、化合物

HRID 278265ノート

反応式

HRID 278265 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]([CH2:19][CH3:20])[N:17]=[C:16]([CH2:21][CH3:22])[C:15]=2[CH3:23])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO>[ClH:24].[ClH:24].[CH2:19]([N:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[C:15]([CH3:23])[C:16]([CH2:21][CH3:22])=[N:17]1)[CH3:20]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21912727HCID 21912727、化合物

生成物 1

HCID 131723149HCID 131723149、化合物収率 92%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 1-(t-butoxycarbonyl)-4-(1,3-diethyl-4-methyl-(1H)-pyrazol-5-yl)piperidine (348 mg) (from Step E) in 2.5 N HCl in methanol was stirred at rt for 16 h. The solution was concentrated and the resulting solid was suspended in ethyl acetate, filtered and dried to afford 293 mg (92%) of the title compound.

後処理

  1. concentrationThe solution was concentrated
  2. filtrationfiltered
  3. customdried

出典と根拠

ORDレコード
ord-1398036eb6344e37bc434aa85c432c23
出典データセット
uspto-grants-2002_03
特許番号
US06358979B1

反応ノート

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