Diazomethane → Methyl 5-methyl-4-hexenoate

HRID 278381

反応式

HRID 278381 の反応式
[N+](=[CH2:3])=[N-].[CH3:4][C:5]([CH3:12])=[CH:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10]>CCOCC>[CH3:4][C:5]([CH3:12])=[CH:6][CH2:7][CH2:8][C:9]([O:11][CH3:3])=[O:10]

参加物

4

反応物 2

HCID 9550DiazomethaneHCID 124253245-Methyl-4-hexenoic acid

生成物 1

HCID 10909672Methyl 5-methyl-4-hexenoate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

Freshly prepared diazomethane in ether was added to an ice-cooled solution of 5-methyl-4-hexenoic acid (4.5 g, 35.16 mmol) in ether (10 mL) until the solution became slightly yellow in color. The solvent was then evaporated under vacuum to afford the title product as a colorless liquid in near quantitative yield (4.90 g). This product was used in the next reaction step without further purification. 1H NMR (CDCl3) δ 1.62 & 1.68 [2s, 6H, C(CH3)2], 2.30 [m, 4H, (CH2)2], 3.69 (s, 3H, COOCH3) and 5.07 (t, 1H, CH).

後処理

  1. customThe solvent was then evaporated under vacuum

出典と根拠

ORDレコード
ord-8719e9fbf4f148e0868d240a4d0102b4
出典データセット
uspto-grants-2002_03
特許番号
US06359120B1

関連ノート

読み込み中…