Acetic Acid → (1S,2R)-(+)-Norephedrine

HRID 27843

反応式

HRID 27843 の反応式
C(O)(=O)C.[N+:5]([CH:8]([CH3:17])[CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[OH:10])([O-])=O>C(O)(C)C>[NH2:5][CH:8]([CH3:17])[CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[OH:10]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 2261182-Nitro-1-phenyl-1-propanol

生成物 1

HCID 4786(1S,2R)-(+)-Norephedrine

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

In the practice of this invention, the 2-nitro-1-phenyl-1-propanol is dissolved in a lower alkyl alcohol, preferably isopropyl alcohol. The mixture is placed in a vessel suitable for high pressure reactions and equipped with agitation means, e.g. a rocking bomb or a stirred bomb. Acetic acid is added to the solution to produce the acetate salt of 2-amino-1-phenyl-1-propanol during the reduction reaction.

後処理

  1. customThe mixture is placed in a vessel suitable for high pressure reactions
  2. customequipped with agitation means, e.g. a rocking bomb

出典と根拠

ORDレコード
ord-4cded8dcbfd6476790085eff15e94b2e
出典データセット
uspto-grants-1980_09
特許番号
US04224246

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