Sodium Acetate → Acetic acid-2-allyl-4-benzyloxy-phenyl ester
反応式
[CH2:1]([C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[CH:6][C:5]=1[OH:18])[CH:2]=[CH2:3].[CH3:19][C:20]([O-])=[O:21].[Na+]>C(OC(=O)C)(=O)C>[CH2:1]([C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[CH:6][C:5]=1[O:18][C:20](=[O:21])[CH3:19])[CH:2]=[CH2:3]参加物
4
反応条件
- 温度
- 80 °C
実験手順
2-Allyl-4-benzyloxy-phenol (2.87 g, 12 mmol) was taken up in acetic anhydride (40 ml) and NaOAc (150 mg, 1.8 mmol) was added and the mixture heated 18 hr at 80° C. After cooling, the reaction mixture was evaporated to afford an oil which was partitioned between EtOAc and H2O (100 ml) and the aqueous phase was extracted with EtOAc (100 ml) and the combined organic phases were dried with MgSO4, filtered and evaporated to afford acetic acid-2-allyl-4-benzyloxy-phenyl ester as a pale yellow oil (3.30 g, 11.7 mmol, 97%), MS: m/e=282.1 (M+).