Hydroxycaprylic Acid → Methyl 2-hydroxyoctanoate

HRID 278462ノート

反応式

HRID 278462 の反応式
[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[C:3]([OH:5])=[O:4].[CH3:12]O.Cl>>[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[C:3]([O:5][CH3:12])=[O:4]

参加物

3

反応物 2

HCID 94180Hydroxycaprylic AcidHCID 21893726Hydrochloride methanol

生成物 1

HCID 10487462Methyl 2-hydroxyoctanoate

実験手順

2-Hydroxyoctanoic acid (1.0 g) was stirred in 10% hydrogen chloride methanol solution (20 ml) at room temperature. After 1.5 hours, the reaction mixture was evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic layer was washed with aqueous NaHCO3 solution and dried over sodium sulfate. Evaporation of the solvent under reduced pressure gave methyl 2-hydroxyoctanoate (0.684 g) as a colorless oil.

後処理

  1. customthe reaction mixture was evaporated under reduced pressure
  2. customThe residue was partitioned between ethyl acetate and water
  3. washThe organic layer was washed with aqueous NaHCO3 solution
  4. dry with materialdried over sodium sulfate
  5. customEvaporation of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-40c1c3396bad46d08b4711877faefc2a
出典データセット
uspto-grants-2002_03
特許番号
US06359145B1

反応ノート

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