化工社化工社 化学情報印刷レポート · 研究参考用
Glyoxylic Acid → (+-)-4-Hydroxymandelic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Glyoxylic Acid | HCID 760 | — |
| 反応物 | Phenol | HCID 996 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (+-)-4-Hydroxymandelic acid | HCID 328 | — |
反応手順
The European patent specification EP-0,368,696 describes the condensation of a glyoxylic acid with phenol in the presence of a water-insoluble amine, to form a 12:84 mixture of 2- and 4-hydroxymandelic acid respectively. Then the excess of phenol is extracted with 1,1-dimethyl-1-methoxypropane. Only 70-74% of the paraisomer, 4-hydroxymandelic acid, is isolated leaving a non-separable mixture of approximately 1:1 2- and 4-hydroxymandelic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06359172B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-89b113ed39194d25bd2436f24bca2c8a |
| 出典メモ | uspto-grants-2002_03 |