Water → 4-Bromo-N,N-diisopropylbenzylamine

HRID 278572ノート

反応式

HRID 278572 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[CH:10]([NH:13][CH:14]([CH3:16])[CH3:15])([CH3:12])[CH3:11].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:13]([CH:14]([CH3:16])[CH3:15])[CH:10]([CH3:12])[CH3:11])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 7912DiisopropylamineHCID 11430Potassium CarbonateHCID 685274-Bromobenzyl bromide

生成物 1

HCID 5987704-Bromo-N,N-diisopropylbenzylamine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

A mixture of 4-bromobenzylbromide (5.0 g), N,N-diisopropylamine (7.85 ml) and potassium carbonate (2.76 g) in dimethylformamide (50 ml) was stirred at 80° C. for 2 hours. To the mixture was added water, and the mixture was extracted with ether. The extract was washed with water, dried (MgSO4) and concentrated to give the title compound (5.0 g).

後処理

  1. extractionthe mixture was extracted with ether
  2. washThe extract was washed with water
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-0947629a38f245a280dfe00ef647a3cd
出典データセット
uspto-grants-2002_03
特許番号
US06359134B1

反応ノート

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