Triethylamine → 1-(4-Carboxybenzenesulfonyl)-4-[4-methyl-2-(4-pyridyl)-5-thiazolecarbonyl]piperazine

HRID 278612ノート

反応式

HRID 278612 の反応式
Cl.Cl.[CH3:3][C:4]1[N:5]=[C:6]([C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)[S:7][C:8]=1[C:9]([N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)=[O:10].C(N(CC)CC)C.Cl[S:31]([C:34]1[CH:42]=[CH:41][C:37]([C:38]([OH:40])=[O:39])=[CH:36][CH:35]=1)(=[O:33])=[O:32]>ClCCl>[C:38]([C:37]1[CH:36]=[CH:35][C:34]([S:31]([N:14]2[CH2:15][CH2:16][N:11]([C:9]([C:8]3[S:7][C:6]([C:17]4[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=4)=[N:5][C:4]=3[CH3:3])=[O:10])[CH2:12][CH2:13]2)(=[O:33])=[O:32])=[CH:42][CH:41]=1)([OH:40])=[O:39]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 823854-(Chlorosulfonyl)benzoic acidHCID 226280481-[4-Methyl-2-(4-pyridyl)-5-thiazolecarbonyl]piperazine dihydrochloride

生成物 1

HCID 226280061-(4-Carboxybenzenesulfonyl)-4-[4-methyl-2-(4-pyridyl)-5-thiazolecarbonyl]piperazine収率 75.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 1-[4-methyl-2-(4-pyridyl)-5-thiazolecarbonyl]piperazine dihydrochloride (180 mg) and triethylamine (253 mg) in dichloromethane (20 ml) was added 4-chlorosulfonylbenzoic acid (108 mg), and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated, and the residue was dissolved in water and neutralized with 1 N hydrochloric acid. The precipitate was filtered, washed with water and dried to give a colorless solid of the title compound (174 mg).

後処理

  1. concentrationThe reaction solution was concentrated
  2. dissolutionthe residue was dissolved in water and neutralized with 1 N hydrochloric acid
  3. filtrationThe precipitate was filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-d6b57f71b3474c069be991bb4b997b2a
出典データセット
uspto-grants-2002_03
特許番号
US06359134B1

反応ノート

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