Methanol → 6-Ethynyl-1-(iso-propyl-methyl-amino)-4,4-dimethyl-1,2,3,4-tetrahydronaphthalene
反応式
[CH3:1][N:2]([CH:21]([CH3:23])[CH3:22])[CH:3]1[C:12]2[C:7](=[CH:8][C:9]([C:13]#[C:14][Si](C)(C)C)=[CH:10][CH:11]=2)[C:6]([CH3:20])([CH3:19])[CH2:5][CH2:4]1.CO.C(=O)([O-])[O-].[K+].[K+]>C(OCC)(=O)C>[C:13]([C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][CH:10]=1)[CH:3]([N:2]([CH:21]([CH3:22])[CH3:23])[CH3:1])[CH2:4][CH2:5][C:6]2([CH3:19])[CH3:20])#[CH:14]参加物
5
反応物 3
生成物 1
試薬・触媒・溶媒 1
実験手順
Following general procedure E and using 1-(methyl-iso-propylamino)-4,4-dimethyl-6-trimethylsilanylethynyl-1,2,3,4-tetrahydro-naphthalene (Intermediate 28, 0.14 g, 0.45 mmol), methanol (5 mL), potassium carbonate (0.61 g, 4.41 mmol) and ethyl acetate the title compound (0.092 g, 80%) was obtained as an oil.
出典と根拠
- ORDレコード
- ord-0319908edafd4646a12714f749dff1d8
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06359135B1
反応ノート
読み込み中…