Potassium Carbonate → 1-[4-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]indole

HRID 2787ノート

反応式

HRID 2787 の反応式
[C:1]1([C:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[C:1]1([C:7]2[CH2:12][CH2:11][N:10]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH:20]=[CH:19]3)[CH2:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 825531,2,3,6-Tetrahydro-4-phenylpyridineHCID 123407571-(4-Chlorobutyl)-1H-indole

生成物 1

HCID 219978811-[4-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]indole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
90 °C

実験手順

A mixture of 4.8 g (30 mmol) of 4-phenyl-1,2,3,6-tetrahydropyridine, 6.22 g of 1-(4-chlorobutyl)indole and 8.3 g of potassium carbonate in 100 ml of dimethylformamide is heated at 90° C. for 3 hours. Evaporation to dryness is then carried out at reduced pressure, the residue is redissolved in chloroform and washing is carried out repeatedly with water. The organic phase is dried with anhydrous sodium sulfate and evaporation is carried out at reduced pressure, a crude product being obtained which is purified by chromatography on silica gel. 5.7 g (17.3 mmol). of 1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]indole are obtained.

後処理

  1. customEvaporation to dryness
  2. dissolutionthe residue is redissolved in chloroform
  3. washwashing
  4. dry with materialThe organic phase is dried with anhydrous sodium sulfate and evaporation
  5. customa crude product being obtained which
  6. customis purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-a1beaa3b1b63410ca82b9562ddec3ef2
出典データセット
uspto-grants-1998_03
特許番号
US05731331

反応ノート

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