Hydrochloric Acid → 3,3'-Dihexyl-2,2'-bithiophene

HRID 278832ノート

反応式

HRID 278832 の反応式
[CH2:1]([Mg]Br)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].Br[C:10]1[CH:14]=[CH:13][S:12][C:11]=1[C:15]1[S:16][CH:17]=[CH:18][C:19]=1Br.Cl>C(OCC)C.Cl[Ni]1(Cl)[P](C2C=CC=CC=2)(C2C=CC=CC=2)CCC[P]1(C1C=CC=CC=1)C1C=CC=CC=1>[CH2:1]([C:10]1[CH:14]=[CH:13][S:12][C:11]=1[C:15]1[S:16][CH:17]=[CH:18][C:19]=1[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 8190873,3'-Dibromo-2,2'-bithiopheneHCID 178444609HCID 178444609、化合物

生成物 1

HCID 114844383,3'-Dihexyl-2,2'-bithiophene収率 100.1%

試薬・触媒・溶媒 2

HCID 178418745HCID 178418745、化合物触媒HCID 3283Diethyl Ether溶媒

実験手順

Hexylmagnesium bromide (100 ml, 2 M solution in diethyl ether, 200 mol) was added dropwise to a solution of 3,3′-dibromo-2,2′-bithiophene (15 g, 46.6 mmol) and Ni(dppp)Cl2 (0.5 g, 0.1 mmol) in 100 ml of diethyl ether at 0° C. The reaction was slightly exothermic and a red brown coloration was observed. After stirred and heated for 24 h, the reaction mixture was cautiously poured into a mixture of crushed ice and diluted HCl solution and extracted with ether. The combined extracts were dried over anhydrous MgSO4 and filtered. After removal of the solvent, the residue was vacuum-distilled to give a clear viscous oil (15.6 g, 81%). 1H-NMR (CDCl3, ppm): δ7.25 (d, 2H, J=5 Hz), 6.96 (d, 2H, J=5 Hz), 2.50 (t, 4H), 1.54 (m, 4H), 1.23 (m, 12H), 0.85 (t, 6H).

後処理

  1. temperatureheated for 24 h
  2. extractionextracted with ether
  3. dry with materialThe combined extracts were dried over anhydrous MgSO4
  4. filtrationfiltered
  5. customAfter removal of the solvent
  6. distillationthe residue was vacuum-distilled

出典と根拠

ORDレコード
ord-843b4f64706a48bc96d032b421ba5e52
出典データセット
uspto-grants-2002_03
特許番号
US06361717B1

反応ノート

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