Dimethylacetamide → [1-(2-tert-butyloxy-2,3-dihydro-1,3-dioxo-1H-benzo[de]isoquinolin-6-yl)-pyrrolidin-3-yl]-carbamic acid, tert-butyl ester
反応式
Br[C:2]1[CH:3]=[CH:4][C:5]2[C:6](=[O:21])[N:7]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[C:8](=[O:15])[C:9]3[C:14]=2[C:13]=1[CH:12]=[CH:11][CH:10]=3.C(C1CCN(N)C1)([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=O.C[C:36]([N:38]([CH3:40])C)=[O:37]>>[C:17]([O:16][N:7]1[C:6](=[O:21])[C:5]2[CH:4]=[CH:3][C:2]([N:7]3[CH2:6][CH2:5][CH:40]([NH:38][C:36](=[O:37])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH2:8]3)=[C:13]3[C:14]=2[C:9](=[CH:10][CH:11]=[CH:12]3)[C:8]1=[O:15])([CH3:20])([CH3:19])[CH3:18]参加物
4
反応条件
- 温度
- 120 °C
実験手順
A mixture of 6-bromo-2-tert-butyloxy-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione (0.5 g, 1.4 mmol, from Example K2) and 3-Boc-aminopyrrolidine (0.8 g, 4.7 mmol) in DMA (4.0 mL) was heated at 120° C. overnight. The mixture was concentrated, and water was added to give a precipitate, which was filtered to yield 0.6 g of the title compound.