Hydrochloric Acid → 3,5-Dichloro-2-isothiocyanatopyridine
反応式
[Cl:1][C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.Cl.[N-]=[C:12]=[S:13]>>[Cl:1][C:2]1[C:3]([N:9]=[C:12]=[S:13])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1参加物
4
実験手順
3,5-Dichloro-2-amino pyridine (8.15, 0.05 mol) was treated with thiophosgenes (10% soln. in toluene, 55 ml). The mixture was refluxed until clear solution was obtained and no further hydrochloric acid gas was being evolved. The mixture was cooled, and the solid which crystallised was removed by filtration. The mother liquors, after evaporation and crystallisation of the residual oil, yielded 5.5 g. (55%) of the required isothiocyanate as pale yellow needles m. pt. 45°-6°.
後処理
- temperatureThe mixture was refluxed until clear solution
- customwas obtained
- temperatureThe mixture was cooled
- customthe solid which crystallised
- customwas removed by filtration
- customThe mother liquors, after evaporation and crystallisation of the residual oil
- customyielded 5.5 g
出典と根拠
- ORDレコード
- ord-dffacfefda164193be659bca22101673
- 出典データセット
- uspto-grants-1980_09
- 特許番号
- US04224331
反応ノート
読み込み中…