2-Butanamine, 3,3-dimethyl- → 3-(Benzo[1,3]dioxol-5-ylamino)-2-(4-chlorophenylsulfonyl)-3-(1,2,2-trimethyl-propylamino)-2-propenenitrile

HRID 279098

反応式

HRID 279098 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH:10][C:11](SC)=[C:12]([S:15]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)(=[O:17])=[O:16])[C:13]#[N:14])=[CH:9][C:4]=2[O:3][CH2:2]1.[CH3:27][CH:28]([NH2:33])[C:29]([CH3:32])([CH3:31])[CH3:30]>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH:10][C:11]([NH:33][CH:28]([CH3:27])[C:29]([CH3:32])([CH3:31])[CH3:30])=[C:12]([S:15]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)(=[O:17])=[O:16])[C:13]#[N:14])=[CH:9][C:4]=2[O:3][CH2:2]1

参加物

3

反応物 2

HCID 5209072-Butanamine, 3,3-dimethyl-HCID 70149709Benzo[1,3]dioxol-5-ylamino-2-(4-chlorophenylsulfonyl)-3-methylsulfanyl-2-propenenitrile

生成物 1

HCID 701504333-(Benzo[1,3]dioxol-5-ylamino)-2-(4-chlorophenylsulfonyl)-3-(1,2,2-trimethyl-propylamino)-2-propenenitrile収率 49%

実験手順

3-(Benzo[1,3]dioxol-5-ylamino-2-(4-chlorophenylsulfonyl)-3-methylsulfanyl-2-propenenitrile (0.327 g, 0.8 mmol) was stirred in 1,2,2-trimethylpropylamine (1 ml) for 22 h at 100° C. under nitrogen in a sealed flask. Work up as described in Example 1, 2) gave 182 mg (49%) of the title compound. Mp 160.5-162° C. 1H NMR (200 MHz, CDCl3): δ=0.78 (s, 9H), 0.9 (d, 3H), 3.22 (m, 1H), 6.0 (br s, 2H), 6.48 (m, 2H), 6.78 (br d, 1H), 7.48 (d,2H), 7.83 (d, 2H). MA C22H24ClN3O4S.0.30 H2O (corrected bruttoformula); calc 56.54%; C, 5.31%; H, 8.99%; N; found: 56.47%; C, 5.25%; H, 8.90%; N.

出典と根拠

ORDレコード
ord-d8e25caafedd44beb1208f519745f901
出典データセット
uspto-grants-2002_03
特許番号
US06362205B1

関連ノート

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