Cyclohexyl phenyl ketone → 1-Benzoyl-1-bromocyclohexane

HRID 279143

反応式

HRID 279143 の反応式
[Br:1]Br.[CH:3]1([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1>C(Cl)Cl.C(O)(=O)C>[Br:1][C:11]1([C:9]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)=[O:10])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

参加物

5

反応物 2

HCID 12837Cyclohexyl phenyl ketoneHCID 24408Bromine

生成物 1

HCID 3447971-Benzoyl-1-bromocyclohexane

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

Temperature was kept at 20-25° C. when bromine (2.8 ml) was added slowly to a stirred mixture of cyclohexylphenyl ketone (10 g) in CH2Cl2 (50 ml) and acetic acid (1 ml). The mixture was stirred at the ambient temperature for 1 hour and extracted with 5% NaHCO3 (2×30 ml) and water (30 ml). The organic phase was dried over Na2SO4 and evaporated. Yield was 14.1 g.

後処理

  1. customwas kept at 20-25° C.
  2. extractionextracted with 5% NaHCO3 (2×30 ml) and water (30 ml)
  3. dry with materialThe organic phase was dried over Na2SO4
  4. customevaporated

出典と根拠

ORDレコード
ord-1601148f930f4f8a90905d4ab52d6087
出典データセット
uspto-grants-2002_03
特許番号
US06362211B1

関連ノート

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