Sulfuric Acid → 2,3,4,4a-Tetrahydro-1H-fluoren-9(9aH)-one

HRID 279145ノート

反応式

HRID 279145 の反応式
[C:1]1([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.OS(O)(=O)=O>>[CH2:2]1[CH:1]2[CH:6]([C:10]3[C:9]([C:7]2=[O:8])=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH2:5][CH2:4][CH2:3]1

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 2492911-Cyclohexenyl phenyl ketone

生成物 1

HCID 6041812,3,4,4a-Tetrahydro-1H-fluoren-9(9aH)-one

実験手順

Cyclohex-1-enylphenyl ketone (9.7 g) was slowly added to a concentrated H2SO4 solution (100 ml) at room temperature and the resulting mixture was placed into a pre-heated oil bath (110° C.) for 20 minutes. The hot mixture was poured into ice-water (400 ml) and extracted with CH2Cl2 (4×40 ml). The organic phase was washed with 5% NaHCO3 solution (2×30 ml) and water (30 ml). After drying over Na2SO4 and evaporation the yield was 9.6 g.

後処理

  1. customthe resulting mixture was placed into a pre-heated oil bath
  2. extractionextracted with CH2Cl2 (4×40 ml)
  3. washThe organic phase was washed with 5% NaHCO3 solution (2×30 ml) and water (30 ml)
  4. dry with materialAfter drying over Na2SO4 and evaporation the yield was 9.6 g

出典と根拠

ORDレコード
ord-6ef9f58064e348c984c5e299010ae57d
出典データセット
uspto-grants-2002_03
特許番号
US06362211B1

反応ノート

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