p-Fluoronitrobenzene → 2-(4-Nitrophenyl)-2h-1,2,3-triazole

HRID 279163ノート

反応式

HRID 279163 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[NH:11]1[CH:15]=[CH:14][N:13]=[N:12]1>O>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:12]2[N:13]=[CH:14][CH:15]=[N:11]2)=[CH:3][CH:4]=1)([O-:10])=[O:9]

参加物

4

反応物 2

HCID 9590p-FluoronitrobenzeneHCID 178418936HCID 178418936、化合物

生成物 1

HCID 2781582-(4-Nitrophenyl)-2h-1,2,3-triazole収率 66.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

4-Fluoronitrobenzene (21 g) was reacted with 1H-1,2,3-triazole (12.4 g) in the same manner as in Reference Example 9. The resultant was cooled and poured into water. The precipitated crystals were collected by filtration and purified by silica gel chromatography (eluent: dichloromethane to dichloromethane/acetone=8/1). The first eluted fraction was recrystallized from dichloromethane-diisopropyl ether to give 2-(4-nitrophenyl)-2H-1,2,3-triazole (18.8 g) as pale yellow prisms.

後処理

  1. temperatureThe resultant was cooled
  2. filtrationThe precipitated crystals were collected by filtration
  3. custompurified by silica gel chromatography (eluent: dichloromethane to dichloromethane/acetone=8/1)
  4. customThe first eluted fraction was recrystallized from dichloromethane-diisopropyl ether

出典と根拠

ORDレコード
ord-fbd7cc109d7e47a9a9616d1326ba7ffc
出典データセット
uspto-grants-2002_03
特許番号
US06362206B1

反応ノート

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